Evolutionary misfiring?

Thought of the day

Who still doesn’t take debit? Honestly. It’s 2010.

New Comedy Central show spurs outrage from poorly named organization

Comedy Central is mulling over a new show called “JC” that will be about Jesus living in modern day New York. It will probably be moderately funny and then get canceled in a couple of seasons (if it’s even that lucky). Unless, of course, the religious get their undue respect and prevent it from airing at all.

Yesterday, the newly-formed Citizens Against Religious Bigotry blasted the cartoon, charging the cable channel with a double standard. In April, Comedy Central censored a “South Park” episode that featured the prophet Muhammad in a bear costume after a radical Muslim group threatened the show creators online. The group of religious and conservative leaders also fired off letters to 250 advertisers, urging them not to buy time on “JC.”

It has apparently been lost on these respect-demanders that religion is the marketplace for bigotry. That may be because they don’t seem to have a definition of bigotry in the first place, but thought isn’t really the point of these groups. They just want to maintain the status quo where religion gets respect it has never earned.

And I love the so-called double standard issue. It’s a logical fallacy – “You weren’t mean to the other guy!” So what? Besides, the point of not showing Muhammad was so they wouldn’t get attacked by those motivated by the most violent religion in the world right now.

I look forward to this fall line up.

June 6

Promising skin cancer news

One of the oldest treatments for cancer in the modern era is to stimulate the immune system. William Coley was one of the pioneers in this technique, coming up with Coley’s Toxin in the late 19th century. This was a mixture that basically involved infecting patients with the bacteria Streptococcus pyogenes. Coley claimed fantastic results, but he kept his records poorly. I don’t know if he ever lied – there is no direct evidence which says he did – but his results were almost always questionable. Besides that, he tended to lose patients to bacterial infections from time to time.

Cancer research lost some of its focus on the immune system in the early part of the 20th century, Coley’s toxin was reclassified into oblivion by the FDA, and governments really didn’t supply the funds for research they should have. Research, however, has long come back around to looking at the immune system and how it can help fight cancerous cells. One of the most recent results has to do with a new drug, Ipilimumab, which is for patients with melanoma

The results, reported Saturday at a cancer conference, left doctors elated.

“We have not had any therapy that has prolonged survival” until now, said Dr. Lynn Schuchter of the Abramson Cancer Center at the University of Pennsylvania, a skin cancer specialist with no role in the study or ties to the drug’s maker.

The drug, ipilimumab, (ip-ee-LIM-uh-mab), works by helping the immune system fight tumors. The federal Food and Drug Administration has pledged a quick review, and doctors think the drug could be available by the end of this year.

Ipilimumab is a T-cell potentiator. T-cells basically have antigens which help to regulate immune responses. These antigens inhibit ‘overreactions’ within the immune system. What ipilimumab does is block this inhibition. It says to the immune system, ‘Run wild, you’re free!’

The increased survival rate is great when measured by percentage – 67% – but the practical numbers only mean a few more months of life. That’s how a lot of cancer research goes, unfortunately, and it makes it all so much less of an elation. But this is still hopeful. It’s good progress on the cancer front. (But do keep in mind, this is just one study for one type of cancer, interesting and promising as it may be.)

Huh

Someone searched these terms to get to FTSOS:

bowel tumor fox terrier

It’s unclear just how that road leads to this site, but here we are, I guess.

Arrogant religion takes another blow

To the chagrin of religious egos, scientists have found Titan has conditions possibly suitable for life.

The first paper, in the journal Icarus, shows that hydrogen gas flowing throughout the planet’s atmosphere disappeared at the surface. This suggested that alien forms could in fact breathe.

The second paper, in the Journal of Geophysical Research, concluded that there was lack of the chemical on the surface.

Scientists were then led to believe it had been possibly consumed by life.

Researchers had expected sunlight interacting with chemicals in the atmosphere to produce acetylene gas. But the Cassini probe did not detect any such gas.

Chris McKay, an astrobiologist at Nasa Ames Research Centre, at Moffett Field, California who led the research, said: “We suggested hydrogen consumption because it’s the obvious gas for life to consume on Titan, similar to the way we consume oxygen on Earth.

It feels good that I don’t need to intentionally misinterpret scientific studies because they contradict long-held, traditionally based beliefs. The fact that there may be other life in our solar system isn’t all that surprising, especially since exceedingly strong evidence for ancient life on Mars has already been confirmed.

More Symphony of Science

My least favorite so far, but here it is.

Explaining denialism

It’s ever so common to come across an evolution denier only to discover the person is also a global warming denier. This may be chalked up to ideology – American conservatism practically demands a god and it’s too pro-business to accept the science of global warming (or at least the predicted consequences). But another reason must often be sought; the denialism can extend beyond a conservative agenda. This includes HIV denial, vaccine denial, second-hand smoke denial, and a host of other forms. In fact, the anti-vax movement will often find sympathies on the left.

Some of the common underlying themes of denialism are alleging conspiracies, moving the goalposts in the face of evidence, and manufacturing evidence. In other words, it’s all very anti-scientific. But it isn’t necessarily an outright hostility towards science that causes this – though many conservatives suffer from such an affliction. Instead, it’s the way many people tend to think.

All denialisms appear to be attempts like this to regain a sense of agency over uncaring nature: blaming autism on vaccines rather than an unknown natural cause, insisting that humans were made by divine plan, rejecting the idea that actions we thought were okay, such as smoking and burning coal, have turned out to be dangerous.

This is not necessarily malicious, or even explicitly anti-science. Indeed, the alternative explanations are usually portrayed as scientific. Nor is it willfully dishonest. It only requires people to think the way most people do: in terms of anecdote, emotion and cognitive short cuts. Denialist explanations may be couched in sciency language, but they rest on anecdotal evidence and the emotional appeal of regaining control.

Emotional appeals are not always bad. When they are mixed with substance, they make for powerful rhetoric. But often, entire arguments are premised in emotion. Take creationism/intelligent design. It isn’t that there’s any evidence for it; many people recognize that natural selection is a blind process which builds piece by piece, bit by bit, thereby not being random and not being improbable, thus making all life the product of purely natural processes. God has no place to go but out. Since no science supports creationism/intelligent design, an emotional response is the result – to the detriment of science.

[Seth Kalichman of the University of Connecticut at Storrs] believes the instigators of denialist movements have more serious psychological problems than most of their followers. “They display all the features of paranoid personality disorder”, he says, including anger, intolerance of criticism, and what psychiatrists call a grandiose sense of their own importance. “Ultimately, their denialism is a mental health problem. That is why these movements all have the same features, especially the underlying conspiracy theory.”

Neither the ringleaders nor rank-and-file denialists are lying in the conventional sense, Kalichman says: they are trapped in what classic studies of neurosis call “suspicious thinking”. “The cognitive style of the denialist represents a warped sense of reality, which is why arguing with them gets you nowhere,” he says. “All people fit the world into their own sense of reality, but the suspicious person distorts reality with uncommon rigidity.”

The likes of Maloney and Moritz certainly fit this profile. Both have had some of the most radical reactions to criticism I’ve seen since grade school, they both are clearly angry (especially Maloney), and both actually have taken measures to expand their web presence upon its destruction by Pharyngula and FTSOS (Moritz on Facebook, Maloney everywhere else), apparently believing what they have to say is too important to be drowned out by facts, evidence, and other pesky things.

But this extends beyond those two. Many creationists fit this profile. Just wait for one to write an editorial to a paper. The emotion, the anger. Then respond. Watch for the screeching about tone, respect, not being nice enough. And I don’t mean to watch for those reactions from my style of writing (though I get those, too). The most tempered response is met with hostility.

But as damaging as denialism has been to science education, it has had more immediate, more serious consequences.

Denialism has already killed. AIDS denial has killed an estimated 330,000 South Africans. Tobacco denial delayed action to prevent smoking-related deaths. Vaccine denial has given a new lease of life to killer diseases like measles and polio. Meanwhile, climate change denial delays action to prevent warming. The backlash against efforts to fight the flu pandemic could discourage preparations for the next, potentially a more deadly one.

If science is the best way to understand the world and its dangers, and acting on that understanding requires popular support, then denial movements threaten us all.

Science is, in fact, the best way of knowing.

The Goonies

We had our hands on the future and we blew it…to save our own lives. Sorry, dad.

~Legit line from The Goonies